A bedroom with a cow on the sleeping bed and a man lying on the floor
Zeleris: florfenicol + meloxicam

An easier way to treat BRD

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When cattle are affected by BRD, they suffer from infection and inflammation.

Effective BRD treatment consists of an effective antibiotic to fight infection and a long-acting NSAID to relieve inflammation.

Bovine Respiratory Disease (BRD)

BRD Infection and inflammation: the two go hand in hand

BRD is an infection of lungs most often caused by bacteria and/or viruses

The presence of these microorganisms in the lungs triggers inflammation

Inflammation is part of the defense mechanism, but it can also cause severe damage to the lungs along with fever, lack of appetite and pain.

Illustration of a syringe

To treat the bacterial infection, an antibiotic is needed, while an anti-inflammatory drug is recommended to reduce other symptoms. Now you can do both in a single shot!

Illustration showing infectious bacteria causing lung inflammation
Cow fever graphic

Fever & Depression

Cow pain graphic


Fluid in lungs graphic

Fluid in the lungs

Lung lesions graphic

Lung lesions

Illustration of a syringe

To treat the bacterial infection, an antibiotic is needed, while an anti-inflammatory drug is recommended to reduce other symptoms. Now you can do both in a single shot!

BRD: A disease with a significant health and economic impact on your herd

BRD is an important cause of death in young stock1,*

A pie graph with BRD at 29%; Diarrhea at 18%; Ruminal Tympani (Bloat) at 9%; Accident at 7%; Other Causes at 37%
Causes of Death



Ruminal Tympani (Bloat)


Other Causes

BRD is associated with dramatic effects on performance2

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Reduced Growth

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Premature Culling

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Reduced Fertility

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Reduced Milk Production

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Stack of cash

BRD is a Costly Disease…
Up to $85 per heifer under 3 months3

Managing BRD and reducing its negative impact on your farm


The goal of BRD treatment is to fight bacteria (antibiotic) and to relieve inflammation (anti-inflammatory)

Florfenicol: a first line low-resistance antibiotic4


Effective & suitable antibiotic

There are a large number of antibiotics available but some are better suited for treating BRD.

An effective antibiotic treatment against BRD should:

  • Be efficient against the main bacteria involved in BRD
  • Provide a fast and lasting effect after a single shot
  • Penetrate well into the lungs for optimal action at the site of infection
  • Minimize the development of bacteria resistance

Meloxicam: a long-acting NSAID


Efficient & long-acting anti-inflammatory

Inflammation has a significant impact on recovery and productivity.

In case of BRD, an effective anti-inflammatory should:

  • Act fast, to minimize the impact of inflammation
  • Have a lasting effect
  • Reduce fever (antipyretic) and alleviate pain (analgesic)

A convenient BRD solution

Dosage Icon

Easy Dosage

1 mL/10 kg (4.5 mL/100 lbs)

Inject Icon

Easy to Inject

Excellent Syringeability

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Single shot

A Powerful combination

C.L.A.S.® (Ceva Layered Anti Shatter) Vial: designed for farm conditions.

Robust and shock resistant for less breakage and losses

Eco-designed vial for less impact on the environment

Zeleris C.L.A.S Vial

Ergonomic grip groove for easier handling

Innovative formula with excellent syringeability

Bovine respiratory disease:
ask for a complete treatment

For optimal treatment success:

Treat as soon as possible

Administer the correct dose considering the animal’s weight

Talk with your veterinarian about treatment protocols

Ask your veterinarian for more information


  1. Boissard, V. Étude de la mortalité bovine en France métropolitaine. Veterinary Thesis. (Vetagro Sup, 2011).
  2. Van der Fels-Klerx, H. J., Martin, S. W., Nielen, M. & Huirne, R. B. M. Effects on productivity and risk factors of Bovine Respiratory Disease in dairy heifers; a review for the Netherlands. NJAS - Wageningen. J. Life Sci. 50, 27–45 (2002).
  3. Van der Fels-Klerx, H. J., Sørensen, J. T., Jalvingh, A. W. & Huirne, R. B. An economic model to calculate farm-specific losses due to bovine respiratory disease in dairy heifers. Prev. Vet. Med. 51, 75–94 (2001).
  4. Anholt, M. et al. Antimicrobial Susceptibility of Bacteria That Cause Bovine Respiratory Disease Complex in Alberta, Canada. Front. Vet. Sci. 4:207 (2017).

This website is intended to provide more information for producers whose vet has recommended Zeleris. Click YES, if you are the intended audience. Click NO, if you are not.